Novobiocin is produced by which genus?

Novobiocin is produced by which genus?

• A. Streptomyces
• B. Penicillium
• C. Micromonospora
• D. Bacillus

Answer: (A)

Novobiocin comes from the soil-dwelling actinobacteria genus Streptomyces, which is famous for producing a wide array of antibiotics through its rich secondary metabolism. This group makes aminocoumarin antibiotics like novobiocin, which work by inhibiting DNA gyrase, specifically targeting the GyrB subunit to block DNA replication. Other listed genera are associated with different antibiotics: Penicillium makes penicillins, Micromonospora yields aminoglycosides such as gentamicin, and Bacillus produces bacitracin. Thus, Streptomyces is the source of novobiocin.

Novobiocin comes from the soil-dwelling actinobacteria genus Streptomyces, which is famous for producing a wide array of antibiotics through its rich secondary metabolism. This group makes aminocoumarin antibiotics like novobiocin, which work by inhibiting DNA gyrase, specifically targeting the GyrB subunit to block DNA replication. Other listed genera are associated with different antibiotics: Penicillium makes penicillins, Micromonospora yields aminoglycosides such as gentamicin, and Bacillus produces bacitracin. Thus, Streptomyces is the source of novobiocin.